If you want to run AetherSX2 on a PC, you'll generally need an Android emulator like BlueStacks or MuMu Player since AetherSX2 was built natively for Android.
However, if you're looking for a smoother experience on PC, you might want to look into NetherSX2 (the community-patched continuation of AetherSX2 or tweak your PCSX2 settings. Whichever route you choose, don't forget that you'll still need to source a legal PS2 BIOS file (like SCPH-70012.bin) to get your games booting! get it from
https://nether-sx2.com/nethersx2-bios/